SMPD3 and neoplasm: We also identified 5 other candidate COMF mutations: an R283W mutation in D-Amino Acid Oxidase (DAO), which is commonly employed as industrial biocatalysts in the production of semi-synthetic cephalosporins and enantiomerically pure amino acids;24 an L99F mutation in Microtubule Associated Monooxygenase 2 (MICAL2), a protein that has been shown to be a tumor-promoter;28 two mutations, D638A and H639P, in Sphingomyelin Phosphodiesterase 3 (SMPD3); and A199P in TIMP Metallopeptidase Inhibitor 3 (TIMP3), a gene known for its potent tumor suppressive functions29.