GNAS and cancer: As expected, the majority of these predicted COMFs (77/125) primarily encoded transcription factors and signaling molecules well-known to be frequently mutated in cancer, such as GNAS, KRAS, and NRAS. The pipeline also identified several mutations in tumor suppressors such as TP53, NF1, and NF2 that likely represent particularly damaging missense mutations that inactivate the gene, rather than COMF mutations.