By combining both KEGG analysis and GO term analysis, seven genes (RNASEH2A, RFC2, RFC4, LIG1, POLD1, POLD2, and POLE4) were identified as new biomarker genes upregulated in CRPC compared to localized Pca and associated with DNA replication and DNA repair (Fig. 1B). This evidence concerns the gene POLE4 and posterior cortical atrophy.