By combining both KEGG analysis and GO term analysis, seven genes (RNASEH2A, RFC2, RFC4, LIG1, POLD1, POLD2, and POLE4) were identified as new biomarker genes upregulated in CRPC compared to localized Pca and associated with DNA replication and DNA repair (Fig. 1B). The gene discussed is POLD1; the disease is posterior cortical atrophy.