In addition, we used Mendelian randomization to analyze the data from GWAS, Fig. 5D shows the causal relationship between multiple cytokines and osteoporosis through forest plot, and the results show that IL-2 as a risk factor has a significant causal relationship with osteoporosis, while IL-7 as a protective factor has a significant causal relationship with osteoporosis. The gene discussed is IL7; the disease is osteoporosis.