To investigate the role of PRMT2 in the establishment of viral latency during initial HIV-1 infection, we utilized a dual-color HIV-1GKO reporter virus, in which the expression of codon-switched EGFP (csGFP) and mKO2 fluorescent proteins are under the control of HIV-1 LTR and the constitutively active elongation factor 1α (EF1α) promoter, respectively (Fig. 3a). The gene discussed is PRMT2; the disease is HIV-1 infection.