SRPX2 and COVID-19: Among invasive ventilated COVID-19 patients compared to severe HAP/CAP patients in 2019, there was significant enrichment (one-sided Wilcoxon test, p < 0.05) of factors involved in motility (VF0237 [flagella], VF0430 [flagella], and VF0473 [polar flagella]); immune modulation (VF0367 [LPS] and VF0309 [PDIM]); adherence (VF0525 [PfbA], VF0418 [Scm], VF0145 [CBPs], and VF0354 [EfaA]); nutritional/metabolic factors (VF0151 [PsaA]), and the effector delivery system (VF0084 [Xcp secretion system]) (Fig. 3k).