In breast cancer, keratin(KRT)8, KRT18, and/or KRT19 indicate luminal subtypes,[1] whereas KRT5, KRT6, KRT14, and/or KRT17 are used for identifying basal subtypes.[2] In addition, specific keratins are associated with certain clinicopathological tumor features and may be able to predict outcomes in patients. The gene discussed is KRT18; the disease is breast cancer.