Furthermore, SCENIC analysis revealed distinct alterations in transcription factor (TF) activities between malignant and normal NK cells, including prominently upregulated activities of MYC, NFKB1, and NFKB2 in malignant cell clusters (Figure S6D, Supporting Information), whose contribution to NKTCL tumorigenesis has been documented.[15] Together, these observations highlight the heterogeneity of malignant NK cells with diverse biological functions and intrinsic malignant nature in NKTCL. Here, NFKB2 is linked to extranodal nasal NK/T cell lymphoma.