Among the various viral genes encoded by EBV, LMP1 is a well‐known tumorigenic factor that has been implicated in tumor progression, invasion, and metastasis in multiple types of cancers.[20] In our study, we identified a specific malignant NK cluster (NK_C9_CXCL13) marked with the unique expression of LMP1, which was presented at the central stage in the developmental process from normal NK to heterogeneous malignant cells. This evidence concerns the gene PDLIM7 and neoplasm.