CD274 and cancer: Our findings unveil that malignant NK cells tangle with TAMs and T cells to foster an immunosuppressive niche within NKTCL TME, a robust strategy allowing cancer to avoid immune destruction.[24] We note that malignant NK cells have upregulated transcription of the PD‐1 pathway, enabling them to regulate exhausted T cells through immunosuppressive interaction of PDL1‐PD1.