Notably, multiple chemokines, including CXCL2, CXCL9, and CXCL10, were predicted to interact with DPP4 from malignant NK cells (Figure S11A, Supporting Information), which is a dipeptidylpeptidase capable of cleaving and degrading these chemokines in cancers.[35, 36] Consistently, we observed a widespread expression of DPP4 in malignant NK clusters (Figure 3B), which was confirmed by both secreted and cellular protein expression through western blotting in NKTCL cells and IF staining assays in NKTCL tumors from our SC‐cohort, respectively (Figure 3C,D). Here, DPP4 is linked to extranodal nasal NK/T cell lymphoma.