These analyses also revealed upregulation of multiple cancer‐related pathways in malignant NK cells, including hypoxia, angiogenesis, CTLA4, NF‐κB, and inflammation signaling pathways, but downregulation of NK cell‐mediated cytotoxicity and its related leptin, nectin, protein secretion, and vesicular transport signaling pathways,[30, 31] compared to normal NK cells (Figure S6B,C, Supporting Information). This evidence concerns the gene CTLA4 and cancer.