TMEM43 and channelopathy: Four of nine variants were located in genes classified as having definite evidence of channelopathy of BrS (SCN5A), LQTS (KCNH2), and CPVT (RYR2), whereas 24 of 27 variants were classified as definite evidence genes susceptible to arrhythmogenic right ventricular cardiomyopathy (ARVC; DSP, PKP2, TMEM43, DSC2, DSG2, JUP), hypertrophic cardiomyopathy (HCM; MYBPC3, MYH7, TNNI3), and dilated cardiomyopathy (DCM; TTN).13–18 One variant (NEXN) was moderate evidence gene related to DCM.