ACTC1 and Arrhythmogenic right ventricular dysplasia: The most common ARVC-related genotypes were in DSP, whereas PKP2 is the most common genotype in the western population.22 Among the HCM-related variants, most genotypes involve variants in eight disease-causing genes encoding cardiac sarcomere proteins (MYH7, MYBPC3, TNNI3, TPM1, MYL2, ACTC1, TNNT2, and MYL3).