For instance, a pathogenic variant of RYR2 or CASQ2 is a diagnostic criterion that can independently confirm CPVT.11 In addition, an unequivocally pathogenic variant of LQTS supports the diagnosis of LQTS in patients with a corrected QT interval in the normal range.11 Therefore, the identification of specific genotypes could enable the molecular diagnosis of an inherited arrhythmia syndrome even without an apparent electrocardiographic abnormality at presentation. Here, CASQ2 is linked to familial long QT syndrome.