Different from its cytosolic paralogs Hsp90α and Hsp90β which govern the folding and activation of a wide array of proteins, the client list of GRP94 remains highly selective to receptors and secretory proteins (Marzec et al, 2012), including some cancer-associated clienteles like Wnt co-receptor LRP6 (Liu et al, 2013) and HER2 (Patel et al, 2013). Here, HSP90B1 is linked to cancer.