IDH1 and cancer: The reasons for the intensification of cancer metabolism as a focus for oncology research include technological advancements such as metabolite profiling by LC-MS, the realization of the importance of nutrient sensing signaling pathways in cancer progression (23), and findings that exemplified the power of metabolites in cancer cell biology such as the oncometabolite D-2-hydroxyglutarate, that is the product of mutant form of the enzyme isocitrate dehydrogenase 1 (IDH1) (24).