LONP1 and amyotrophic lateral sclerosis: As for physiological roles of polyP, many reports have appeared (protein polyphosphorylation (58), protein folding (59, 60), LON protease regulation (61), vacuolar proteolysis required for autophagy (36), transcriptional regulations (62), blood coagulation (63), relevance to amyotrophic lateral sclerosis/ALS (64), replicative lifespan (65), etc. See the following comprehensive reviews (66, 67)).