The aim of this study was to investigate whether biomarkers of impaired glucose tolerance (fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk factors (low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, systolic blood pressure (SBP), and diastolic blood pressure (DBP)) influence the risk of infertility using an MR-based approach. The gene discussed is INS; the disease is Impaired glucose tolerance.