HESX1 and cyclic hematopoiesis: In this study, to identify the molecular etiology of CH in 47 patients, we screened 11 candidate genes (i.e., GH1, GHRHR, PROP-1, POU1F1, HESX1, LHX3, LHX4, SOX2, SOX3, GLI2, and OTX2) associated with CH using next-generation sequencing (NGS).