Our previous studies of RET knockdown in human SK-N-SH neuroblastoma cells (Chatterjee and Chakravarti, 2019), which expresses all known members of the RET-EDNRB GRN and shows ligand (GDNF)-dependent RET activation, and in mice with a RET LoF mutation, demonstrated that many genes within this GRN are transcriptionally affected by complete RET deficiency [1,29]. The gene discussed is GDNF; the disease is neuroblastoma.