SLC22A3 gene that encodes organic cation transporter 3 (OCT3), playing a significant role in the transporting and clearance of toxic substances of many drugs, including metformin and histamine [25, 26], and several studies confirmed an association between SLC22A3 polymorphisms and the increased susceptibility to cardiovascular diseases [27, 28]. This evidence concerns the gene SLC22A3 and cardiovascular disorder.