LPA and cardiovascular disorder: However, several genes have been found to affect different cardiovascular disorders, such as the SLC22A3-LPAL2-LPA gene cluster [19], and some of these genes considered disease-causing genes such as the myocyte enhancer factor 2A (MEF2A) gene [20], a member of the MEF2 family, together with MEF2B, MEF2C, and MEF2D encodes the transcription factors that control the expression of numerous muscle-specific genes.