Multivariate Cox-proportional hazard model analysis was first conducted using hsa-mir-1247-3p, KIF20A, RAB3B, ORC1L, and DLGAP5 expression, MDSC, Th2, and HSC infiltration, LUAD cancer patient age and cancer stage as covariates to identify key markers promoting loss of patient survival rate. Here, ORC1 is linked to cancer.