N-acetyltransferase 10 (NAT10), is a lysine acetyltransferase (KAT) that acetylates multiple RNAs, which belongs to the general control non-repressible 5 (GCN5)-related N-acetyltransferase (GNAT) family.4–7 As reported, NAT10 can affect cellular physiology by acting as an acetylation regulator to modulate RNA transcription and stability.8–10 More importantly, NAT10 is related to the progression of various malignant tumors, such as hepatocellular carcinoma,11 pancreatic cancer,12 and breast cancer.13 However, the role of NAT10 in LSCC has not been reported in detail. Here, NAT10 is linked to hepatocellular carcinoma.