FOXM1 and cancer: Forkhead box M1 (FOXM1) is a known transcription factor17,18 and a positive effector of the Wnt pathway.19 Elevated FOXM1 expression is observed in various human malignant tumors, and silencing of FOXM1 can efficiently suppress the malignant phenotype of cancer cells.20,21 Importantly, multiple studies have demonstrated the critical role of FOXM1 in LSCC as well.22–24 Therefore, uncovering novel regulating mechanisms of FOXM1 is conducive to providing new insights into the therapeutic strategies against LSCC.