For instance, FOXM1 is a prognostic factor and an enhancing factor in small cell lung cancer;32 it can enhance the 5-FU resistance of colorectal cancer33 and accelerate ovarian cancer cell migration;34 FOXM1-mediated molecular pathway can aggravate bladder cancer via modulation of cell cycle process.35 Additionally, the critical role of FOXM1 in LSCC has been reported as well.22–24 However, whether NAT10-mediated regulating mechanism can alter FOXM1 expression remains unknown. The gene discussed is NAT10; the disease is urinary bladder carcinoma.