Wider (50–60 nm) riboMERCs were identified in metastatic HT-1080 fibrosarcoma cells and in HEK293 cells where they are regulated by the Gp78 E3 ubiquitin ligase and interaction between mitochondrial outer membrane protein 25 (OMP25), also called Synaptojanin-2-binding protein (SYNJ2BP), and its ER partner, ribosome-binding protein 1 (RRBP1), respectively (Hung et al., 2017; Wang et al., 2015). The gene discussed is SYNJ2BP; the disease is fibrosarcoma.