Recent studies have demonstrated that alterations in synaptic‐associated proteins, specifically PSD‐95 and Syn, play a pivotal role in modulating synaptic plasticity in response to pain and depression (Shen et al., 2020; Zhang et al., 2019), thus highlighting the intricate relationship between these molecular changes and the modulation of synaptic plasticity. Here, DLG4 is linked to major depressive disorder.