EA effectively mitigates both CIP and anxiety by activating parvalbumin neurons in the anterior cingulate cortex (Shao et al., 2021), inducing an increase in neurotensin/neurotensin receptor expression (Du et al., 2020), and inhibiting protein kinase Mzeta activity (Du et al., 2017). This evidence concerns the gene PVALB and hereditary sensory and autonomic neuropathy.