ELOVL4 and Stargardt disease 3: VLC-PUFAdeficiency is specifically associated with (i) Stargardt-like maculardystrophy (STGD3)14−16 and (ii) infertility.27 STGD3 is a disease with autosomal dominant inheritance caused byat least three different mutations in the ELOVL4 elongase-expressinggene.14−16 It manifests as a juvenile aggressive degenerationof the macular region of the retina, with rapid progression leadingto early vision loss.