Analyses of serially collected blood from Gpr91−/− mice and WT littermate controls, which were injected with rAAV8-D377Y-mPcsk9 and fed a WTD for 14 weeks, confirmed the expected development of hypercholesterolaemia–in both groups, an approximately 8-fold increase in plasma cholesterol and a 4-fold increase in triglycerides was observed after 2 weeks of injection and diet, and 19-fold increased cholesterol and 8-fold increased triglycerides levels were observed at the endpoint. Here, SUCNR1 is linked to Hypercholesterolemia.