SMAD2 and Hepatic fibrosis: Both TGF-beta and SMAD2/4 have a well-recognized role in heart fibrosis [89,90,91]; likewise, miR-338-3p and let-7a regulate cardiac fibrosis and hypertrophy [92,93,94,95], while miR-182 has a role in pulmonary and liver fibrosis [96,97].