Physiologically, the elevation of the intracellular NAD+/NADH ratio constitutes a resource for the development of aggressive phenotypes in cells of multiple malignancies, whose expression of tNOX correlates positively with exacerbations of proliferation, survival, and tumor progression, according to a series of works through loss- and gain-of-function strategies [85,86,87,88]. This evidence concerns the gene ENOX2 and neoplasm.