In urothelial papilloma cells (RT4 line) exposed to a concentration of 100 μM, the activation of the serine/threonine kinase ataxia telangiectasia-mutated (ATM) was detected, whose known role in the response to DNA damage due to oxidative stress [122] allowed its involvement to be predictable. The gene discussed is ATM; the disease is urothelial papilloma.