TP53 and melanoma: Finally, in this line of evidence, two recent works demonstrated that the mechanistic tNOX/SIRT1/p53 axis also underlies the inhibitory effects of CAP in two human cell types of tongue squamous cell carcinoma (SAS and HSC-3 cell lines) [96], one of human malignant melanoma (A-357 cell line), and one of mouse melanoma (B16–F10) [88], although in these four cancer cell types, cellular autophagy contributed at different levels to the final cytotoxicity.