TRPV6 and neoplasm: Other factors, such as the expression level of tNOX and the probable absence of TRPV6 in 5637 and TMC-1 [83,95] cells, could have scope as variables both in terms of the study of the mechanisms that underlie their refractoriness to CAP and in terms of the possible identification of tumor phenotypes that could indicate signs of contraindication to experimental therapy with capsaicinoids.