On the contrary, in another study, FAF1 degradation was directly postulated as a mediating event of CAP-induced apoptosis in two cell types of murine fibrosarcoma induced by methylcholanthrene (Meth A and CMS5 cells), whose exposure to CAP (100 μM for 72 h) led to rapid increases in ROS generation (also starting from 2 h, with a maximum peak during the 4th h), FAF1 degradation, and significant increases in cell apoptosis. This evidence concerns the gene FAF1 and fibrosarcoma.