TP53 and gastric cancer: This was also reported in gastric cancer cells (AGS) that, after being depleted of p53 via siRNA methodology, experienced abrogation in the proteolytic activation of caspases 9 and 3, preserving the mitochondrial residence of cytochrome c and survival after an incubation of 12 h to CAP (200 μM), while their p53 wild-type counterparts underwent a significant increase in apoptotic activity [115].