ANGPTL8 and Intervertebral disk degeneration: On the other hand, the results of Liao et al. [23] indicated that ANGPTL8 plays an adverse role in the progression of intervertebral disc degeneration (IDD) and that the silencing of ANGPTL8 could reduce ECM degradation and inflammation in human NP cells via inhibition of the NF-κB signaling pathway.