Here, we will investigate emerging evidence that resident and circulating naive ILC2 recruited to mucosal sites can differentiate into mature ILC2 that steadily produce IL-10 in response to molecules such as IL-2, IL-4, IL-10, IL-33, neuromedin-u (NMU) and retinoic acid (RA) (Table 1). This evidence concerns the gene IL4 and rheumatoid arthritis.