CD274 and obesity due to melanocortin 4 receptor deficiency: The cohort with the highest PD-L1 expression who also had obesity (BMI ≥ 30) had the lowest hazard for death (HR 0.48, 95% CI 0.34–0.66) and for progression (HR 0.78, 95% CI 0.62–0.96, Table 1).