SPRYD7 and neoplasm: SPRYD7 was here observed to be involved in invasion, adhesion, and migration in vitro and in liver homing and tumor growth in vivo, which might be enhanced by the high angiogenic capacity induced by SPRYD7 overexpression, as well as by the proteins identified here as dysregulated by SPRYD7 or as SPRYD7 interactors, which have also been demonstrated to be involved in inflammation or cancer.