Importantly, despite the fact that confirmed via qPCR and WB the overexpression of SPRYD7 in KM12C and KM12SM CRC cells prior to proteomics analyses via TMT, we could not observe a significant overexpression of SPRYD7 (Supplementary Table S4) via mass spectrometry (1.01 ratio SPRYD7/mock in KM12C cells and 1.11 in KM12SM cells). Here, SPRYD7 is linked to colorectal carcinoma.