Here, we have investigated the role in CRC progression and metastasis of a barely known protein, SPRYD7, not previously associated with CRC, which was described as upregulated by SILAC in the membrane subcellular compartments of highly metastatic KM12SM CRC cells in comparison to their isogenic poorly metastatic KM12C cells [15]. This evidence concerns the gene SPRYD7 and colorectal carcinoma.