Finally, as potential limitations of the study, although the role of SPRYD7 in CRC has been confirmed in this work via different in vitro and in vivo assays, further investigation of its role in the induction of angiogenesis and CRC progression might be performed via loss-of-function assays after a stable depletion of SPRYD7 in CRC cells to further confirm the here-obtained results. The gene discussed is SPRYD7; the disease is colorectal carcinoma.