The SPRYD7 interactors identified via LC-MS/MS were involved in immune and inflammatory responses, which might be related to the greater induced angiogenic capacity of CRC cells overexpressing SPRYD7, as well as in anchoring functions or actin cytoskeleton, as previously observed for proteins dysregulated due to SPRYD7 overexpression, suggesting the high importance of these pathways in the study of SPRYD7-associated roles in CRC. This evidence concerns the gene SPRYD7 and colorectal carcinoma.