A comprehensive analysis of genomic alterations in the eight UFMylation family genes (UFM1, UBA5, UFC1, UFL1, UfBP1, CDK5RAP3, UfSP1, and UfSP2) across the TCGA database of 33 cancer types identified 55 recurrent and focal somatic copy number alteration events in UFMylation family genes [105]. The gene discussed is UFSP2; the disease is cancer.