Notably, the assessment of CSF levels in different groups of sporadic PD patients revealed that inflammatory markers of the monocyte–macrophage signaling and chemotaxis pathway (Intercellular Adhesion Molecule 1 (ICAM-1), IL-8, MCP-1, Macrophage inflammatory protein-1 beta (MIP-1 beta), and SCF) seem to play a relevant role in PD-associated inflammation [35]. This evidence concerns the gene CSF2 and Parkinson disease.