-↑ Cognitive and exploratory behavior and mitochondrial function.-↓ TNF-α, GSK3-β, RMP2, P-H2A.X, 8-OHDG, CCO and ATP.-↓ Anxiety and depression, Aβ42 oligomers, and reactive astrogliosis.-↑ Modulates synaptic proteins. The gene discussed is TNF; the disease is major depressive disorder.