GPIHBP1 and atherosclerosis: This prevents hypermethylation of the glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) promoter, allowing for GPIHBP1 expression and binding to lipoprotein lipase, ultimately increasing triglyceride breakdown and preventing plaque buildup in an Apolipoprotein E (ApoE) murine knockout model of atherosclerosis [60].