This prevents hypermethylation of the glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) promoter, allowing for GPIHBP1 expression and binding to lipoprotein lipase, ultimately increasing triglyceride breakdown and preventing plaque buildup in an Apolipoprotein E (ApoE) murine knockout model of atherosclerosis [60]. This evidence concerns the gene APOE and atherosclerosis.