TET2 and pulmonary arterial hypertension: Subsequently, many genes have been identified that predispose to PAH, most of which are inherited as autosomal dominant mutations with variable penetrance, including BMP/TGF-β family members (ACVRL1, BMPR1B, GDF2, ENG, CAV1, SMAD1, SMAD4, and SMAD9), ion channels and transporters (KCNK3, KCNA5, ATP13A3, and AQP1), transcription factors (SOX17, TBX4, and KLF4), miscellaneous genes (KDR, PTGIS, RNF213, FBLN2, and PDGFD), as well as the demethylation regulator, TET2.