DNMT3A and systemic sclerosis: These studies of DNMT3A are particularly relevant to the cohort of patients with associated PAH (APAH), a group that is primarily comprised of female patients with scleroderma, CREST syndrome, or systemic lupus, as these patients are inflamed, and no gene has yet been identified as being enriched in this cohort, which accounts for ~40% of all group 1 PH.