Recently, Zhang and Qin demonstrated that in patients with lower extremity deep vein thrombosis, lncRNA LINC00659 facilitated the DNMT3A-mediated methylation (Figure 5) of the fibroblast growth factor 1 (FGF1) promotor, which inhibited the proliferation and angiogenesis ability of endothelial progenitor cells [95]. The gene discussed is DNMT3A; the disease is deep vein thrombosis.