Moreover, in pancreatic ductal adenocarcinoma, the PKM2 in the glycolytic metabolon was shown to be associated with the plasma membrane and the resulting production of ATP is important to guarantee a sufficient supply of ATP to the plasma membrane Ca2+ ATPase in order to avoid cytotoxic Ca2+ overload, e.g., in conditions of severe hypoxia [37]. This evidence concerns the gene PKM and pancreatic ductal adenocarcinoma.