AKT1 and diabetes mellitus: The top scoring differentially expressed miRNAs, which are all downregulated in DM LEC-derived Exos, such as miR-381-3p, miR-199a/b, miR-134-5p, miR-152-3p, and miR-34a-5p (Table 1), are involved in regulating cell cycles, TGF-β signaling, FGF, DNA methylation, PI3K/AKT, Notch signaling, and wound healing.