The T2 inflammatory response is frequently associated with atopy (i.e., the genetic tendency to develop allergic diseases, such as allergic rhinitis, asthma, and atopic dermatitis, associated with heightened immune responses to diverse antigens/allergens, leading to CD4+ Th2 differentiation and overproduction of immunoglobulin E (IgE)) [48], eosinophilic disorders, and parasitic infections [49]. Here, IGHE is linked to asthma.