T2 airway inflammation in patients with asthma, although occurring along a continuum, is characterized by a specific set of cytokines, including IL-4, IL-5, IL-13, and the so-called alarmins, IL-25 and IL-33, and thymic stromal lymphopoietin (TSLP), secreted by activated epithelial cells. The gene discussed is TSLP; the disease is asthma.