At the same time, CRP has anti-inflammatory effects: it stimulates the release of anti-inflammatory agents such as IL-10 and IL-1Rα, and, while activating the complement system, it also recruits several complement inhibitors, possibly in a time-dependent manner.182 As a result, the net effect of CRP in vivo appears to be weakly anti-inflammatory.183 In addition, IL-6 stimulating production of acute phase proteins such as CRP can occur in the absence of inflammation, rather than as in ALS as part of clearance of damaged cells. This evidence concerns the gene CRP and amyotrophic lateral sclerosis.