Monocytes/microglia express CD14 early in ALS, preceding onset.200 There is also increased CD14 in spinal cord tissue in ALS patients.171 Soluble CD14 (sCD14) is a 40 kDa part of the CD14 receptor that is cleaved from the cell surface and released after monocyte activation. The gene discussed is CD14; the disease is amyotrophic lateral sclerosis.