IL10 and amyotrophic lateral sclerosis: At the same time, CRP has anti-inflammatory effects: it stimulates the release of anti-inflammatory agents such as IL-10 and IL-1Rα, and, while activating the complement system, it also recruits several complement inhibitors, possibly in a time-dependent manner.182 As a result, the net effect of CRP in vivo appears to be weakly anti-inflammatory.183 In addition, IL-6 stimulating production of acute phase proteins such as CRP can occur in the absence of inflammation, rather than as in ALS as part of clearance of damaged cells.