Studies have shown that inactivation of CARM1 could sensitize tumors to T‐cell dependent antitumor immunity and that interferon γ (IFN‐γ), which is derived from tumor‐infiltrating CD8+ T cells, could trigger tumor cell ferroptosis.[24, 30, 31] Considering that our study showed that EZM2302 stabilized ACSL4 by inhibiting CARM1, we proposed that EZM2302 sensitizes colon cancer cells to anti‐PD‐1 immunotherapy by promoting ferroptosis, whereas anti‐PD1 enhances EZM2302‐induced tumor cell ferroptosis. Here, CARM1 is linked to malignant colon neoplasm.