CDH1 and neoplasm: The authors embedded cells with and without E‐cadherin expression into a 3D collagen I matrix and found that E‐cadherin‐negative cells showed lower migratory persistence and displacement, suggesting the importance of E‐cadherin in the growth, invasion, dissemination, and metastatic colonization of tumor tissue (Figure 9b).[171] These results indicated that studying cadherin function in tumor tissues can aid in developing desired heterogeneous tumor models.