Their interaction with tumor cells can modulate tumorigenesis and reveal new therapeutic opportunities.[101] Conversely, CAFs promote cancer invasion and metastasis by secreting matrix‐crosslinking enzymes that alter the extracellular matrix (ECM) to increase tissue stiffness.[102, 103] Furthermore, CAFs secrete various signaling molecules, like TGF‐β, HGF, GAS6, and VEGF, which enhance tumor invasion, proliferation, and angiogenesis (Figure 4c). This evidence concerns the gene HGF and neoplasm.