For example, the intestinal probiotic E. coli Nissle 1917 has been engineered as a targeted transport vector carrying anticancer genes to tumor hypoxic regions, such as tumor suppressor azurin (Zhang et al., 2012), p53, and/or anti-angiogenic factor Tum-5 (He et al., 2019), followed by high copy amplification and efficient expression of these anticancer genes, inducing cancer-killing effect and suppressing tumor growth. Here, TP53 is linked to neoplasm.