However, key cytokines like IL-10 and TGF-β have been linked to both a protective effect and no effect of HBO2 treatment in sepsis [12, 17], and the effect of important transcription factors such as hypoxia inducible factors and NF-κB appears to be dependent on both the preconditional stage of hypoxia and inflammation, as well as the timing and number of consecutive hyperbaric sessions [11, 18]. The gene discussed is NFKB1; the disease is Sepsis.