Although we cannot exclude that p62-immunoreactive aggregates include other material than just lipofuscins or that the Ser236 antibody used herein may have different labelling properties compared to the Ser240 epitope, we suggest our five cases and NFL being the same disease to be classified according to the updated FCD classification scheme of 2022 [44] as: MRI-positive DEPDC5- or NPRL3-altered Focal Cortical Dysplasia ILAE Type IIa. Here, DEPDC5 is linked to Focal cortical dysplasia.