In this way, VISTA suppression in aged mice led to spontaneous stimulation of CD8+ and CD4+ T cells and loss of tolerance [83], implying the significance of VISTA in autoimmunity, as its knockdown in autoimmune diseases, including systemic lupus erythematosus, was found to exacerbate the disease [85]. This evidence concerns the gene VSIR and systemic lupus erythematosus.