For example, a case-control study of the Iranian population discovered a significant link between TIM-3 SNPs and MS susceptibility, with -574 and -1516 C>A SNPs in the promoter region of the TIM-3 gene posing a risk for MS development, while A/C genotypes for the -574 and -1516 loci of the TIM-3 gene were significantly lower in MS patients [118]. This evidence concerns the gene HAVCR2 and myeloid sarcoma.