CD4 and myeloid sarcoma: Another study on CD4+ T cell clones derived from MS patients' CSF revealed that these cells released more IFN-γ than control subjects, exhibited downregulated expression of T-bet and TIM-3, and when polarized under Th1 conditions that evoke T-bet and TIM-3 expression, clones from control subjects upregulated TIM-3 at much higher rates than T cell clones from MS patients [121].