CTLA4 and myeloid sarcoma: Likewise, a study by Palacios et al. discovered a decline in CTLA-4 isoforms expression associated with some alleles of SNP 658 in MS patients, but they inferred that the epigenetic alterations are mainly regulated by the disease itself and the implication of CTLA-4 in MS is roughly attributable to functional changes in its pathway [146].