Furthermore, we demonstrated that pro-SFTPB negatively regulates PGK1 protein levels by binding to ADRM1 and suppressing complex formation by ADRM1, hRpn2 and UCH37; this weakened ADRM1/hRpn2/UCH37 complex-mediated PGK1 deubiquitination, thereby facilitating degradation of the PGK1 protein in NSCLC. The gene discussed is SFTPB; the disease is non-small cell lung carcinoma.