Notably, inhibition of Akt activity by the Akt inhibitor MK2206 (Fig. 3d) significantly suppressed the increase in colony formation in soft agar (Fig. 3e) and the increased invasion by NSCLC cells (Fig. 3f) that were otherwise induced by downregulation of pro-SFTPB expression. The gene discussed is SFTPB; the disease is non-small cell lung carcinoma.