To wit, Rspo2 neutralization and recombinant DKK1 could effectively ameliorate the proliferative capacity, migratory capacity, invasive capacity, and proinflammatory cytokines production in FLS, as well as inhibit catabolism and enhance anabolism in chondrocyte homeostasis, which might be implicated in the onset and progression of RA. Here, RSPO2 is linked to rheumatoid arthritis.