BACH1 and non-small cell lung carcinoma: Collectively, our findings suggest that HIF-1α can affect lncRNA AC016727.1 expression and that lncRNA AC016727.1 regulates HIF-1α expression via BACH1, thereby forming a hypoxia-mediated lncRNA AC016727.1/BACH1/HIF-1α signaling loop in NSCLC (Fig. 9).