A similar greater proportion of patients with abnormal ECG, atrial fibrillation/flutter, pacemaker/implantable cardioverter-defibrillator, and higher values of the cardiac biomarkers (Troponin T, NT-proBNP) were observed in the ATTRwt amyloidosis subgroup as compared to the ATTRv amyloidosis subgroup. The gene discussed is NPPB; the disease is atrial fibrillation.