ATTR amyloidosis may be caused by one of over 130 pathogenic mutations that destabilize the TTR protein (hereditary ATTR amyloidosis [ATTRv amyloidosis]) or the accumulation of non-mutated TTR protein (wild-type ATTR amyloidosis [ATTRwt amyloidosis]) [3, 4]. The gene discussed is TTR; the disease is amyloidosis.