Variants in ARX have been associated with several X-linked intellectual disability (XLID) syndromes, including XL lissencephaly, developmental and epileptic encephalopathy type 1 (DEE1) and Partington syndrome [96], reflecting the central role of this member of the homeobox gene family of TFs in controlling the formation of many brain structures during early embryonic development. Here, LBX1 is linked to developmental and epileptic encephalopathy, 1.