BMP4 and microphthalmia: Pathogenic variants in this bone morphogenetic protein have previously been associated with anophthalmia-microphthalmia and digital anomalies [110] (OMIM #607932) and cleft-lip palate [111] (OMIM #600625) and indeed the patient presented with several features of this syndrome including anophthalmia and clefting, and hence, BMP4 is considered a good candidate by the referring clinician.