The p53 family members (p53, p63 and p73) are strongly altered at the genomic level in a cohort of HNSCC human samples analyzed with the OncoPrint profiling from the TCGA Firehose Legacy dataset through the cBioportal platform (71%, 26% and 7% genomic and/or transcriptomic alterations, respectively). This evidence concerns the gene TP63 and head and neck squamous cell carcinoma.