From a molecular point of view, the amplification or deregulated expression of the genomic locus encoding for one of the members of the p53 family [17, 18], p63, is a frequent event in HNSCC [19], beyond the contribution of p53 itself [20–23], whose genomic alteration is present in 70% of HNSCC cases [24]. Here, TP53 is linked to head and neck squamous cell carcinoma.