In the future, the relationship between miR-3653-3p and NLRP3, caspase 1, and IL-1β in patients with schizophrenia is worthy of in-depth research and further validating the potential of miR-3653-3p, NLRP3, caspase 1, and IL-1β as a stable biomarker for schizophrenia in diagnostic experiments. Here, CASP1 is linked to schizophrenia.