Finally, we detected miR-3653-3p and NLRP3, Caspase 1 and IL-1β mRNA and explored the relationship between miR-3653-3p and NLRP3, Caspase 1, IL-1β in peripheral blood of schizophrenia; we look forward to searching for stable biomarkers of schizophrenia in peripheral blood. This evidence concerns the gene IL1B and schizophrenia.