To some extent, this could not directly reflect the negative regulatory function of miR-3653-3p and ensure whether NLRP3/Caspase1/IL-1β is a regulatory axis in schizophrenia, but this indicates miR-3653-3p, NLRP3, caspase 1 and IL-1β are closely related in schizophrenia. The gene discussed is IL1B; the disease is schizophrenia.