Intriguingly, IL-1β is thought to be the result of enlarged inflammation in the mother, but as a cause of schizophrenia in the offspring, it has been conjectured that blood–brain barrier damage may occur in the early years or even in the fetal periods, then peripheral inflammation interacts with central immune activation in schizophrenia [4, 25, 26]. Here, IL1B is linked to schizophrenia.