Finally, we detected miR-3653-3p and NLRP3, Caspase 1 and IL-1β mRNA and explored the relationship between miR-3653-3p and NLRP3, Caspase 1, IL-1β in peripheral blood of schizophrenia; we look forward to searching for stable biomarkers of schizophrenia in peripheral blood. The gene discussed is CASP1; the disease is schizophrenia.