We further tested another two USP7 inhibitors, HBX41108 [45] and P5091 [41], in the lung cancer cell H1299 and colon cancer cell HCT116, and found that both inhibitors dramatically upregulate USP22 in H1299 (Fig. 1B) and HCT116 (Fig. 1C). Here, USP22 is linked to malignant colon neoplasm.