USP7, also known as herpes virus associated protease (HAUSP), regulates the deubiquitination of histone H2B monoubiquitinion (H2Bub1) [4] and the stability of multiple proteins including p53-MDM2 [5, 6], β-catenin [7] PTEN [8], and FOXP3/4 [9], and is involved in diverse cellular processes including DNA transcription, DNA damage response (DDR), epigenetic control of gene expression, immune response, and viral infection [10]. The gene discussed is USP7; the disease is viral infectious disease.