We found that the addition of 0.5, 2.5 μM of FT671 significantly elevated USP22 luciferase reporter activity (Fig. 2A) and 1.25 μM FT671 induced a dynamic increase of USP22 mRNA level (Fig. 2B) in both A549 and H1299 lung cancer cells. Here, USP22 is linked to lung carcinoma.