USP7 and malignant colon neoplasm: We further tested another two USP7 inhibitors, HBX41108 [45] and P5091 [41], in the lung cancer cell H1299 and colon cancer cell HCT116, and found that both inhibitors dramatically upregulate USP22 in H1299 (Fig. 1B) and HCT116 (Fig. 1C).