As the main members of the DUBs family, ubiquitin-specific peptidases (USPs) are involved in numerous cellular processes including those frequently altered in carcinogenesis such as cell growth and survival; and increasing studies have indicated that dysregulated USPs represent potential targets for cancer treatment, and functional studies have also generally found that multiple DUBs are involved in these same processes, suggesting considerable redundancy in DUB-regulated processes [3]. Here, ZUP1 is linked to cancer.