LMNA and progeroid syndrome: A point mutation (c.1824 C > T; p.G608G) in the Lamin A (LMNA) gene, leading to a mis-splicing event that results in the loss of 50 amino acids from the Lamin A protein (Fig. 3a), which is characterized by Hutchinson–Gilford progeria syndrome (HGPS or progeria) [9, 13, 15].